David cuerdon portrait retouching toolkit12/27/2023 ![]() This study aims to document the nature and progression of spontaneous speech impairment suffered by patients with Alzheimer's disease (AD) over a 12-month period, using both cross-sectional and prospective longitudinal design. In addition, although replicating some aspects such as anomia, of what is already known about the language impairments in these two conditions, the study provides novel findings for both that could help clinicians in syndromic classification of anomic speech. All speech samples were recorded during a face-to-face interview and were subjected to a well-controlled quantitative analysis.Outcomes & Results: Our results suggest that (a) the picture description task is more sensitive to abnormalities in the semantic measures, whereas the interviews are better at exposing morpho-syntactic deficits (b) circumlocution is not, as has sometimes been claimed, a salient feature of speech in SD (c) increases in the frequency of hesitation markers and of phonological and syntactic errors are prominent features of language decline in mild AD and (d) a 150-word interview sample is adequate to provide a realistic reflection of language impairment.Conclusions: This study compared, for the first time, the two most commonly used methods of eliciting connected speech and documented many similarities in results from the two but also some salient differences in their sensitivity to specific aspects of language deficit. Connected speech analysis provides the most realistic measure of language function but its use has been restricted by operational constraints.Aims: In this prospective study we assessed the relative utility of a picture description task and a semi-structured interview in exposing the language decline in semantic dementia (SD) and typical mild Alzheimer's disease (AD), compared to each other and to healthy volunteers.Methods & Procedures: Our cohort comprised 16 patients with a clinical diagnosis of SD, 20 with mild typical AD, and 30 healthy participants. Errors point to a breakdown in lexical semantic processing, which occurs earlier in the disease process than previously reported.īackground: Neurodegenerative syndromes are associated with varying degrees of language impairment. Performance on the latter task indicated that minimal AD patients and healthy controls could be differentiated on several measures of semantic processing. Although both pictures could differentiate between the AD patients and the healthy controls, results suggested that the complex task was most sensitive. The task assessed several aspects of spontaneous speech, including melodic line, articulation, grammatical form, phrase length, paraphasias, word-finding difficulties, error monitoring, information conveyed, and information content. Twenty-two AD patients (11 minimal and 11 mild) and 22 age- and education-matched healthy controls, were assessed on a simple and complex picture description task. ![]() Although distinctive patterns of language impairment have been identified in Alzheimer's Disease (AD) patients, few studies have been conducted to identify the errors that consistently differentiate minimal and mild AD patients from healthy elderly individuals.
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